René Lafont Selected Research

norbixin

1/2022	Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance.
1/2021	A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin.
1/2020	Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.
1/2016	Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.

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René Lafont Research Topics

Disease

4	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 01/2016
3	Inflammation (Inflammations) 01/2021 - 02/2012
2	COVID-19 12/2021 - 01/2021
2	Vision Disorders (Hemeralopia) 01/2020 - 01/2016
2	Obesity 04/2014 - 02/2012
1	Respiratory Insufficiency (Respiratory Failure) 12/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Stargardt Disease 01/2020
1	Eye Diseases (Eye Disease) 01/2020
1	Phototoxic Dermatitis (Phototoxicity) 01/2016
1	Insulin Resistance 02/2012
1	Dehydration (Water Stress) 01/2002

Drug/Important Bio-Agent (IBA)

4	norbixinIBA 01/2022 - 01/2016
3	A2-E (N-retinylidene-N-retinylethanolamine)IBA 01/2021 - 01/2016
3	Ecdysterone (20 Hydroxyecdysone)IBA 01/2021 - 02/2012
2	LipidsIBA 01/2019 - 04/2014
1	Antiviral Agents (Antivirals)IBA 12/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021
1	Angiotensin Receptor AntagonistsIBA 01/2021
1	Angiotensin-Converting Enzyme 2IBA 01/2021
1	Angiotensin Receptors (Angiotensin II Receptor)IBA 01/2021
1	diazepinylbenzoic acidIBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	LuteinIBA 01/2020
1	AntioxidantsIBA 01/2020
1	Carotenoids (Carotene)IBA 01/2020
1	LipofuscinIBA 01/2020
1	ZeaxanthinsIBA 01/2020
1	Leukotriene A4IBA 01/2019
1	Leukotriene B4IBA 01/2019
1	AminopeptidasesIBA 01/2019
1	leukotriene A4 hydrolaseIBA 01/2019
1	Retinal Pigments (Pigments, Visual)IBA 01/2016
1	Retinaldehyde (Retinal)IBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 04/2014
1	Plasminogen Activator Inhibitor 1IBA 02/2012
1	Messenger RNA (mRNA)IBA 02/2012
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2012
1	OsteopontinIBA 02/2012
1	AdipokinesIBA 02/2012
1	muristerone AIBA 01/2002
1	ajugasterone CIBA 01/2002
1	turkesteroneIBA 01/2002
1	EcdysteroidsIBA 01/2002